BY MARK SCHOLZ, MD PSA testing is an essential part of prostate cancer treatment, and it is done at various stages in a patient’s journey. Initial PSA screening of healthy …
Tag: PSA Relapse
Even though PSA has been questioned as a tool for screening, it’s the Gold Standard for confirming cancer recurrence. However, a PSA rise from a low-grade recurrence that may not require treatment. Determining the difference between a low-grade recurrence and a high-grade recurrence is heavily influenced by the rate of PSA doubling.
For a PSA relapse, treatment usually consists of testosterone inactivating pharmaceuticals (TIP) given intermittently. For example, after TIP is started, PSA usually drops to less than 0.1. Treatment is continued for 6 to 12 months. After TIP is stopped and the effects wear off, testosterone recovers and PSA will begin to rise. A second cycle of TIP is restarted when the PSA reaches a certain threshold (usually between 3 and 6). Immunotherapy administered during the holiday period may slow the rise in PSA and delay the need for restarting TIP.