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Azure (High-Risk) also contains three subtypes. Low-Azure is Gleason 4+4=8 with all other criteria being favorable—two or less positive biopsy cores, no biopsy core more than 50% involved with cancer, a PSA less than 10 and minimal or no palpable disease (T1c or T2a). Men with Low-Azure can consider having treatment along the lines of what is used for High-Teal. High-Azure is defined by having at least one of the following: A PSA over 40, Gleason 9 or 10, more than 50 percent positive biopsy cores, or cancer that spreads overtly outside the prostate. Basic-Azure falls between the Low and High subtypes. Basic-Azure is managed aggressively with and extended duration of hormonal therapy, seeds and IMRT as is High-Azure, possibly though with the addition of Zytiga and or Taxotere.